|Name||Prof. Dr. Harald Steiner|
|Place of birth||Stuttgart, Germany|
|Date of birth||05.02.1965|
|since 2007||Apl. Professor of Biochemistry at the LMU München|
|seit 2007||Akademischer Oberrat at the Adolf- Butenandt- Institute of the LMU München|
|2003-2007||Akademischer Rat at the Adolf- Butenandt- Institute of the LMU München|
|2002||Habilitation at the LMU München|
|1999-2003||Wissenschaftlicher Assistent at the Adolf- Butenandt- Institute of the LMU München|
|1996-1999||Postdoctoral scientist at theZI Mannheim, Department of Molecular Biology, University of Heidelberg|
|1996||Doctorate (Dr. rer nat.) at the LMU München|
|1992||Degree (Dipl.-Chem.) at the University of Stuttgart|
g-Secretase is one of two proteases responsible for the generation of the Alzheimer´s disease causing amyloid b-peptide (Ab).Understanding the precise mechanism of Ab generation is crucial for drug targeting the disease.
The Alzheimer Research Award of the Hans and Ilse Breuer Foundation strongly supports our research activities on an in-depth functional and structural characterization of g-secretase. This ambitious project concentrates on the purification of g-secretase and the analysis of its molecular architecture, on the role of modulatory interactors of g-secretase, such as CD147 and TMP21, on the identification of additional g- secretase modifiers, on the identification and characterization of g-secretase substrate and modulator binding sites, as well as on g-secretase subunit structure-function analyses.