Prof. Dr. Magdalena Götz

Spenden & Helfen

Curriculum vitae

Name  Prof. Dr. Magdalena Götz
Date of birth  17.01.1962
since 2004 Chair of Physiological Genomics, Medical Faculty, LMU Munich, Germany
since 2004 Director (C4) Stem Cell Institute, GSF – seit 01.01.2008: Helmholtz Zentrum München, Neuherberg-Munich, Germany
1997-2003 Research group leader at the Max-Planck Institute of Neurobiology, Munich-Martinsried, Germany
2000 Habilitation (Zoology)
1997 Scientist at the Max-Planck Institute of biophysical Chemistry, Göttingen, Germany
1994-1996 Postdoctoral Scientist at SmithKline Beecham Harlow, U.K.
1993-1994 Postdoctoral fellow at the National Institute for Medical Research, London, U.K.
1992-1993 Postdoctoral fellow at the Friedrich-Miescher Institute of the Max-Planck Society, Tübingen, Germany
1992 PhD-Thesis (summa cum laude)
1989-1992 PhD at the Friedrich-Miescher Instituteof the Max-Planck Society, Tübingen, Germany
1989 Diplome of Biology, University of Tübingen, Germany

Project description

Glial cells as source for new neurons in AD mouse models

The project will investigate the changes in glial cells in AD mouse models and examine the best neurogenic fate determinants to reactivate neurogenesis in the adult cerebral cortex of these mouse models.


Selected publications

A) Original publications
Götz, M. and J. Bolz (1989) Development of vasoactive intestinal polypeptide (VIP)-containing neurons in organotypic slice cultures from rat visual cortex. Neurosci. Lett. 107: 6-11.

Bolz, J., N. Novak, M. Götz and T. Bonhoeffer (1990). Formation of target-specific neuronal projections in organotypic slice cultures from rat visual cortex. Nature 346: 359-362.

Götz, M. and J. Bolz (1992) Preservation and formation of cortical layers in slice cultures. J.Neurobiol. 23: 783-802.

Götz, M., N. Novak, M. Bastmeyer, and J. Bolz (1992) Membrane bound molecules in rat cerebral cortex regulate thalamic innervation. Development 116: 507-519.

Götz, M. and J. Bolz (1994) Differentiation of transmitter phenotypes in rat cerebral cortex. Eur.J.Neurosci. 6: 18-32.

Götz, M., B.P. Williams, J. Bolz, and J. Price (1995) The specification of neuronal fate: a common precursor for neurotransmitter subtypes in the rat cerebral cortex in vitro. Eur.J. Neurosci. 7: 889-898.

Hübener, M., M. Götz, S. Klostermann, and J. Bolz (1995) Guidance of thalamocortical axons by growth-promoting molecules in developing rat cerebral cortex. Eur.J.Neurosci. 7: 1963-1972.

Götz, M., A. Wizenmann, S. Reinhardt, A. Lumsden, and J. Price (1996) Selective adhesion of cells from different telencephalic regions. Neuron 16: 551-564.

Henke-Fahle, S., F. Mann, M. Götz, K. Wild, and J. Bolz (1996) A dual action of a carbohydrate epitope on afferent and efferent axons in cortical development. J.Neurosci. 16: 4195-4206.

Götz, M., J. Bolz, A. Joester, and A. Faissner (1997) Tenascin-C synthesis and influence on axonal growth during rat cortical development. Eur.J. Neurosci. 9: 496-506.

Stoykova, A., M. Götz, P. Gruss, and J. Price (1997) Pax6-dependent regulation of adhesive patterning, R-cadherin expression and boundary formation in developing forebrain. Development 124: 3765-3777.

Götz, M., A. Stoykova, and P. Gruss (1998) Pax6 controls radial glia differentiation in the cerebral cortex. Neuron 21: 1031-1044.

Chapouton, P., A. Gärtner, and M. Götz (1999). The role of Pax6 in restricting cell migration between developing cortex and basal ganglia. Development 126: 5569-5579.

Malatesta, P., E. Hartfuss, and M. Götz (2000). Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage. Development 127: 5253-5263.

Malatesta, P., M. Götz, G. Barsacchi, F. Tirone, J. Price, R. Zoncu, and F. Cremisi (2000). PC3 overexpression affects the pattern of cell division of rat cortical precursors. Mechanisms of Development 90: 17-28.

Hartfuss, E., R. Galli, N. Heins and M. Götz (2001). Characterization of CNS precursor subtypes and radial glia. Dev. Biol. 229: 15-30.

Heins, N., F. Cremisi, P. Malatesta, R.M.R. Gangiemi, G. Corte, J. Price, G. Goudreau, P.Gruss and M. Götz (2001) Emx2 promotes symmetric cell divisions and a multipotential fate in precursors from the cerebral cortex. Molecular and Cellular Neuroscience 18: 485-502.

Chapouton, P., C. Schuurmans, F. Guillemot, and M. Götz (2001) The transcription factor Neurogenin 2 restricts cortical cell migration in the developing mouse telencephalon. Development 128: 5149-5159.

v.Frowein, J., K. Campbell, and M. Götz (2002) Expression of Ngn1, Ngn2, Cash1, Gsh2 and Sfrp1 in the developing chick telencephalon. MOD 110: 249-252.

Heins, N., P. Malatesta, F. Cecconi, M. Nakafuku, K. L. Tucker, M. A. Hack, P. Chapouton, Y. Barde and M. Götz (2002) Generation of neurons from glial cells: the role of the transcription factor Pax6. Nature Neuroscience 5: 308-315.

Malatesta, P., E. Hartfuss, M.A. Hack, W. Klinkert, F. Kirchhoff, H. Kettenmann and M.Götz (2003) Neuronal or glial progeny: regional differences in radial glial fate. Neuron 37: 751-764.

Stoykova, A., O. Hatano and M. Götz (2003) Increase of reelin-positive cells in the Pax6-mutant mouse cortex. Cerebral Cortex 13: 560-571.

Hartfuss, E., E. Förster, H. H. Bock, M. A. Hack, P. Leprince, J.M. Luque, J. Herz, M. Frotscher and M. Götz (2003) Reelin signalling directly affects radial glia morphology and biochemical maturation. Development 130: 4597-609.

Hack, M.A., M. Sugimori, C. Lundberg, M. Nakafuku and M. Götz (2004) Regionalization and fate specification in neurospheres: the role of Olig2 and Pax6. Molecular and Cellular Neuroscience 25: 664-678.

Bibel, M., J. Richter, K. Schrenk, K. L. Tucker, V. Staiger, M. Korte, M. Götz and Y.-A. Barde (2004) Differentiation of mouse embryonic stem cells into a defined neuronal lineage. Nature Neurosci. 7: 1003-1009.

Koutmani, Y., C. Hurel, E. Patsavoudi, M. Hack, M. Götz, D. Thomaidou and R. Matsas (2004) BM88 is an early marker of proliferating precursor cells that will differentiate into the neuronal lineage. Eur. J. Neurosci. 20: 2509-2523.

Nieto, M., E. S. Monuki, H. Tang, J. Imitola, N. Haubst, S. Khoury, J. Cunningham, M. Götz and C. A. Walsh (2004) Expression of Cux-1 and Cux-2 in the subventricular zone and upper layers II-IV of the cerebral cortex. Journal Comp. Neurol. 479: 168-180.

Haubst, N., J. Berger, V. Radjendirane, J. Graw, J. Favor, G.F. Saunders, A. Stoykova and M. Götz (2004) Molecular dissection of Pax6 function: the specific roles of the paired and homeodomain in brain development. Development 131: 6131-6140.

Hack, M., A. Saghatelyan, A. de Chevigny, P.-M. Lledo and M. Götz (2005) Neuronal fate determinants of adult olfactory bulb neurogenesis. Nature Neuroscience 8: 865-872.

Buffo, A., M. Vosko, D. Ertürk, G. Hamann, M. Jucker, D. Rowitch and M. Götz (2005) Expression pattern of the transcription factor Olig2 in response to brain injuries - implications for neuronal repair. PNAS 102: 18183-18188.

Stricker, S.H., K. Meiri and M. Götz (2006) P-GAP43 is enriched in horizontal cell divisions throughout rat cortical development. Cerebral Cortex 16: i121-131.

Von Frowein, J., A. Wizenmann and M. Götz (2006) The transcription factors Emx1 and Emx2 suppress choroid plexus development and promote neuroepithelial cell fate. Developmental Biology 296: 239-252.

Adolf, B., P. Chapouton, C. S. Lam, S. Topp, B. Tannhäuser, U. Strähle, M. Götz and L. Bally-Cuif (2006) Conserved and acquired features of adult neurogenesis in the zebrafish telencephalon. Developmental Biology 295: 278-293.

Mori, T., K. Tanaka, A. Buffo, W. Wurst, R. Kühn and M. Götz (2006) Inducible gene deletion in astroglia and radial glia – a valuable tool for functional and lineage analysis. Glia 54: 21-31.

Haubst, N., E. Georges-Labouesse, A. DeArcangelis, U. Mayer and M. Götz (2006) Basement membrane attachment is dispensable for radial glial cell fate and proliferation, but affects positioning of neuronal subtypes. Development 133: 3245-3254.

Cappello, S., A. Attardo, X. Wu, T. Iwasato, S. Itohara, M. Wilsch-Braeuninger, H.M. Eiken, M.A. Rieger, T.T. Schroeder, W. Huttner, C. Brakebusch and M. Götz (2006) The Rho-GTPase cdc42 regulates cortical precursor fate at the apical surface. Nature Neuroscience 9: 1099-1107.

Holm, P.C., M.T. Mader, N. Haubst, A. Wizenmann, M. Sigvardsson and M. Götz (2007) Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon. Molecular and Cellular Neuroscience 34: 99-119.

Berninger, B., F. Guillemot and M. Götz (2007) Directing neurotransmitter identity of neurons derived from expanded adult neural stem cells Eur. J. Neurosci. 25: 2581-2590.

Berninger, B., M. R. Costa, U. Koch, T. Schroeder, B. Sutor, B.Grothe and M. Götz (2007) Functional properties of neurons derived from in-vitro reprogrammed postnatal astroglia. J. Neurosci. 27: 8654-8664.

Ninkovic, J., Mori, T. and M.Götz (2007) Distinct modes of neuron addition in adult mouse neurogenesis. J.Neurosci. 27: 10906-10911.

Costa, M.R., N. Kessaris, W.D. Richardson, M. Götz and C. Hedin-Pereira (2007) The marginal zone/layer I as a novel niche for neurogenesis and gliogenesis in developing cerebral cortex. J. Neurosci. 27: 11376-11388.

Sirko, S., A. von Holst, A. Wizenmann, M. Götz and A. Faissner (2007) Chondroitin sulfate glycosaminoglycans control proliferation, radial glia cell differentiation and neurogenesis in neural stem/progenitor cells. Development 134: 2727-2738.

Ma, L., R. Cantrup, A. Varrault, D. Colak, N. Klenin, M. Götz, S. McFarlane, L. Journot and C. Schuurmans (2007) Zac1 functions through TGF to negatively regulate cell number in the developing retina. Neural Development 8: 2-11.

Nikoletopoulou, V., N. Plachta, N. Allen, L. Pinto, M. Götz and Y.-A. Barde (2007)
Neurotrophin Receptor-Mediated Death of Misspecified Neurons Generated from Embryonic Stem Cells Lacking Pax6. Cell Stem Cell 1: 529-540.

Costa, M.R., G. Wen, A. Lepier, T. Schroeder and M. Götz (2008) Par complex proteins promote self-renewing progenitor divisions in the developing mouse cerebral cortex. Development 135: 11-22.

Buffo A., I. Rite, P. Tripathi, A. Lepier, D. Colak, A.-P. Horn, T. Mori and M. Götz (2008). Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain. PNAS 105:3581-3586.

Colak D., T. Mori, M.S. Brill, A. Pfeifer, S. Falk, C. Deng, R. Monteiro, C. Mummery, L. Sommer and M. Götz (2008). Adult Neurogenesis Requires Smad4-Mediated Bone Morphogenic Protein Signaling in Stem Cells. Journal of Neuroscience 28: 434-446.

Brill M., M. Snapyan, H. Wohlform, J. Ninkovic, M. Jawerka, G.S. Mastick, R. Ashery-Padan, A. Saghatelyan, B. Berninger and M. Götz (2008). A Dlx2- and Pax6-dependent transcriptional code for periglomerular neuron specification in the adult olfactory bulb. Journal of Neuroscience 28, 6439-6452.

Bonilla S., A.C. Hall, L. Pinto, A. Attardo, M. Götz M., W.B. Huttner and E. Arenas (2008). Identification of midbrain floor plate radial glia-like cells as dopaminergic progenitors. Glia 56, 809-820.

Pinto L., M.T. Mader, M. Irmler, M. Gentilini, F. Santoni, D. Drechsel, R. Blum, R. Stahl, A. Bulfone, P. Malatesta, J. Beckers and M. Götz (2008). Prospective isolation of functionally distinct radial glial subtypes-Lineage and transcriptome analysis. Mol Cell Neurosci. 38, 15-42.

Falk, S., H. Wurdak, L.M. Ittner, F. Ille, G. Sumara, M.-T. Schmid, K. Draganova, K.S. Lang, C. Paratore, P. Leveen, U. Suter, S. Karlsson, W. Born, R. Ricci, M. Götz and L. Sommer (2008). Brain area-specific effect of TGF signaling on WNT-dependent neural stem cell expansion. Cell Stem Cell 2, 472-483.

Bergami, M., R. Rimondini, S. Sauri, R. Blum, M. Götz and M. Canossa (2008). Deletion of TrkB in adult progenitors alters newborn neurons integration into hippocampal circuits and increases anxiety like behaviour. PNAS 105, 15570-15575.

Dimou, L., C. Simon, F. Kirchhoff, H. Takebayashi and M. Götz (2008). Progeny of Olig2-expressing progenitors in the grey and white matter of the adult mouse cerebral cortex. Journal of Neuroscience 28, 10434-10442.

Costa, M.R., O. Buchholz, T. Schroeder and M.Götz (2009). Late origin of glia-restricted progenitors in the developing mouse cerebral cortex. Cerebral cortex (in press).

Snapyan, M, M. Lemasson, M.S. Brill, M. Blais, M. Massouh, J. Ninkovic, C. Gravel, F. Berthod, M. Götz, P.A. Barker, A. Parent and A. Saghatelyan (2009). Vasculature guides migrating neuronal precursors in the adult mammalian forebrain via BDNF signaling. J. Neurosci. (in press).

Robel, S., T. Mori, Z. Soubaa, J. Schlegel, S. Sirko, A. Faissner, S. Goebbels, L. Dimou and M. Götz (2009). Conditional deletion of b1 integrin in astroglia causes partial reactive gliosis. Glia (revised version submitted).

B) Reviews and articles in books

Bolz, J. and M. Götz (1992) Mechanisms to establish specific thalamocortical connections in the developing brain. In Development of the central nervous system in vertebrates S.C. Sharma and A.M. Goffinet, eds. pp. 173-187, Plenum Press, New York.

Götz, M. (1992) Über Keime. Zu einer Biologie der Ursachen. In Schmutz und Sauberkeit. Wasser. Schwabe &Co. AG, Basel, 225-240.

Bolz, J., M. Götz, M. Hübener, and N. Novak (1993) Reconstructing cortical connections in a dish. Trends Neurosci. 16: 310-316.

Götz, M. and J. Price (1994) Cell fate and axonal projections from the cerebral cortex.
Sem.Dev.Biol. 5: 359-369.

Price, J., Grove, E., Williams, B., Iavachev, I., McNaugthon, L. and M. Götz (1994) Labelling neural precursor cells with retroviruses. Gene Ther. 1: 4-5.

Götz, M. (1995) Getting there and being there in the cerebral cortex. Experientia 5: 359-369.

Price, J., B.P. Williams and M. Götz (1995) The generation of cellular diversity in the cerebral cortex. In: Development of the Cerebral Cortex, Ciba Foundation Symposium 193. Eds. Bock, G.R. and G. Cardew, Wiley & Sons, Chichester; p. 71-79.

Roberts, G.W., M.C. Royston and M.Götz (1995) Pathology of cortical development and neuropsychiatric disorders. In: Development of the Cerebral Cortex, Ciba Foundation Symposium 193. Eds. Bock, G.R. and G. Cardew, Wiley & Sons, Chichester; p. 296-316.

Götz, M., A. Stoykova, A. Wizenmann, A. Lumsden, P. Gruss and J. Price (1997) How to become the right neuron at the right place: neuronal fate and positional specification in the developing forebrain. In: Molecular basis of axon growth and nerve pattern formation, Taniguchi Symposia on Brain Sciences 20. Ed. H. Fujisawa. pp.37-51.

Götz, M. (1998) How are neurons specified: master or positional control? Trends Neurosci. 21: 135-136.

Götz, M. (1998) Transmitting transmitter phenotypes. Perspectives of Developmental Neurobiology 5: 145-157.

Götz, M. (1999) Cerebral Cortex development. Encyclopedia of Life Sciences, Nature Publishing Group, London,

Götz, M. (2001) Gliazellen bilden Nervenzellen – Radiale Glia als Stammzellen des ZNS von Vertebraten. Neuroforum 01/2001, 3-10.

Götz, M., E. Hartfuss and P. Malatesta (2002) Radial glial cells as neuronal precursors - a new perspective on the correlation of morphology and lineage restriction in the developing cerebral cortex of mice. Brain Res. Bull. 57 (6): 777-788.

Götz, M. and Campbell, K. (2002) Radial glia: Multipurpose cells for vertebrate brain development. TINS 25: 235-238.

Götz, M. (2003) Brain development: Glial cells generate neurons – implications for neuropsychiatric disorders. In: Disorders of Brain and Mind II, Eds. M. Ron, T. Robbins. Cambridge University Press.

Götz, M. (2003) Glial cells generate neurons – master control within CNS regions. The Neuroscientist 9: 379-397.

Kriegstein, A. and M. Götz (2003) Radial glia diversity: a matter of cell fate. Glia 43: 37-43.

Götz, M. (2003) Doublecortin finds its place. Nature Neurosci. 6: 1245-1247.

Götz, M. and Y.-A. Barde (2005) Radial glial cells: defined and major intermediates between embryonic stem cells and CNS neurons. Neuron 46: 369-372.

Götz, M. and L. Sommer (2005) Cortical development: the art of generating cell diversity. Development 132: 3325-3332.

Götz, M. and W. B. Huttner (2005) The cell biology of neurogenesis. Nature Reviews Molecular Cell Biology 6: 777-788.

Mori, T., A. Buffo and M. Götz (2005) The novel roles of glial cells revisited: The contribution of radial glia and astrocytes to neurogenesis. Current Topics in Developmental Biology 69: 67-99.

Berninger, B., M.A. Hack and M. Götz (2006) Neural stem cells: on where they hide, in which disguise, and how we may lure them out. Handb. Exp. Pharmacol. 174: 319-360.

Haubst, N., J. Favor and M. Götz (2006) The role of Pax6 in the nervous system in development and adulthood: master control regulator or modular function? In Transcription factors in Development. Ed. Thiel, Wiley Press.

Stricker, S.H. and M. Götz (2006) Go with the flow: signalling from the ventricle directs neuroblast migration. Nature Neurosci. 9: 470-472.

Ninkovic. J. and M. Götz (2007) Signalling in adult neurogenesis: from stem cell niche to neuronal networks. Curr. Opin. Neurobiol. 17: 338-344.

Pinto, L. and M.Götz (2007) Radial glia heterogeneity – The source of diverse progeny in the CNS. Progress in Neurobiology 83: 2-23.

Lie, C. and M.Götz (2007) Adult neurogenesis – similarities and differences in stem cell fate, proliferation, migration and differentiation in distinct forebrain regions. Cold Spring Harbour Series.

Götz, M., C. Heinrich and L. Dimou (2009) Neurogenesis and glial cells after brain injury. Physiological Reviews (submitted)

Götz, M. (2009) Reactive gliosis: a new source of neural stem cells. Nature Reviews Neuroscience (submitted).

C) Editor of Special Issues
Current Opinion in Neurobiology, 13 (1), 2003. Editorial: p.3-7.
Glia, 43 (1), 2003. Editorial: p. 1-3.