Ausgewählte Publikationen von Dr. med. Lars Bertram

  • Schjeide BMM, Schnack C, Lambert JC, Lill CM, Kirchheiner J, Tumani H, Otto M, Tanzi RE, Lehrach H, Amouyel P, von Arnim C, Bertram L "The role of CLU, CR1, and PICALM on Alzheimer's disease risk and CSF biomarker levels" Arch Gen Psychiat (in press).
  • Bertram L, Lill CM, Tanzi RE (2010) "The genetics of Alzheimer's disease: Back to the future" Neuron 68(2):270-81.
  • Sleegers K, Lambert JC, Bertram L, Cruts M, Amouyel P, Van Broeckhoven C (2010) "The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects" Trends Genet [Epub ahead of print].
  • Bertram L, Tanzi RE (2009) "Genome-wide association studies in Alzheimer's disease" Hum Mol Genet 18(R2):R137-45.
  • Bertram L (2009) "Alzheimer's disease genetics: current status and future perspectives" Int Rev Neurobiol 84:167-84.
  • Fardo DW, Becker KD, Bertram L, Tanzi RE, Lange C (2009) "Recovering unused information in genome-wide association studies: the benefit of analyzing SNPs out of Hardy-Weinberg equilibrium" Eur J Hum Genet 17(12):1676-82.
  • Khoury MJ, Bertram L, Boffetta P, et al. (2009) “Genome Wide Association Studies, Field Synopses and the Development of the Knowledge Base on Genetic Variation and Human Diseases” Am J Epi 170(3):269-79.
  • Schjeide BMM, Hooli B, Parkinson M, Hogan MF, DiVito J, Mullin K, Blacker D, Tanzi RE, Bertram L (2009) “Follow-up of genome-wide association results suggests GAB2 as an Alzheimer's disease susceptibility gene” Arch Neurol 66(2):250-4.
  • Schjeide BMM, McQueen MB, Mullin K, DiVito J, Hogan MF, Parkinson M, Lange C, Blacker D, Tanzi RE, Bertram L (2009) “Assessment of Alzheimer’s disease case-control associations using family-based methods” Neurogenetics 10(1):19-25.
  • Bertram L, Schjeide BMM, Holi B, Mullin K, Hiltunen M, Soininen H, Ingelsson M, Lannfelt L, Blacker D, Tanzi RE (2008) “No Association between CALHM1 and Alzheimer’s Disease Risk” Cell 135(6):993-4
  • Bertram L, Lange C, Mullin K, et al. (2008) “Genome-wide association analysis reveals novel Alzheimer’s disease susceptibility loci in addition to APOE” Am J Hum Genet 83(5):623-32.
  • Bertram L, Tanzi RE (2008) “Thirty Years of Alzheimer’s Disease Genetics: Implications from Systematic Meta-analyses” Nat Rev Neurosci 9(10):768-78.
  • Lu A, Hiltunen M, Romano DM, Soininen H, Hyman BT, Bertram L, Tanzi RE (2008) "Effects of ubiquilin 1 on the unfolded protein response" J Mol Neurosci 38(1):19-30. Epub 2008 Oct 25.
  • Bertram L (2008) “The Genetics of Schizophrenia: Current Status and Future Perspectives” Schiz Bull 34(5):806-12.
  • Kavvoura FK, McQueen M, Khoury MJ, Tanzi RE, Bertram L, Ioannidis JPA (2008) “Evaluation of the potential excess of statistically significant findings in reported genetic association studies: application to Alzheimer's disease” Am J Epi 168(8):855-65.
  • Allen NC, Bagade S, McQueen MB, Ioannidis JPA, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L (2008) "Systematic Meta-Analyses and Field Synopsis of Genetic Association Studies in Schizophrenia: The SzGene Database" Nat Genet 40(7):827-34.
  • McQueen MB, Bertram L, Lange C, Becker KD, Albert MS, Tanzi RE, Blacker D. (2007) “Exploring Candidate Gene Associations with Neuropsychological Performance.” Am J Med Genet (B) Neuropsychiatr Genet 144(8):987-91.
  • Bertram L, Mullin K, Parkinson M, Hsiao M, Moscarillo TJ, Wagner SL, Becker KD, Velicelebi G, Blacker D, Tanzi RE (2007) “Is alpha-T catenin (VR22) an Alzheimer’s disease risk gene?” J Med Genet 44(1):e63.
  • Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE (2007) “Systematic Meta-Analyses of Alzheimer’s Disease Genetic Association Studies: The AlzGene Database.” Nat Genet 39(1):17-23.
  • Bertram L, Hsiao M, McQueen MB, Parkinson M, Mullin K, Blacker D, Tanzi RE (2007) " The LDLR Locus in Alzheimer's disease: A Family-based Study and Meta-Analysis of Case-Control Data" Neurobiol Aging 28(1):18.e1-4. Epub 2005 Dec 27.
  • Hiltunen M, Lu A, Thomas AV, et al. (2006) “Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion” J Biol Chem 281(43):32240-53.
  • Bertram L, Parkinson M, McQueen MB, Mullin K, Hsiao M, Menon R, Moscarillo TJ, Blacker D, Tanzi R (2005) “Further evidence for LBP-1c/CP2/LSF association in Alzheimer’s disease families” J Med Genet 42(11):857-62.
  • Bertram L, Tanzi RE (2005) “The Genetic Epidemiology of Neurodegenerative Disease.” J Clin Invest 115(6):1449-57.
  • Bertram L, Hsiao M, Mullin K, Parkinson M, Menon R, Moscarillo T, Blacker D, Tanzi RE (2005). “ACAT1 is not associated with Alzheimer’s disease in two independent family-based samples” Mol Psychiatry 10(6):522-4.
  • Tanzi RE, Bertram L (2005) “Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective.” Cell 120(4):545-55.
  • Bertram L, Hiltunen M, Parkinson J, et al. (2005) “Family-based association between Alzheimer’s disease and variants in UBQLN1” N Engl J Med 352(9):884-94.
  • Bertram L, Tanzi RE (2004)“Alzheimer’s Disease: One Disorder, Too Many Genes?” Hum Mol Genetics 13(S1): R135-141.
  • Bertram L, Parkinson M, Mullin K, Menon R, Blacker D, Tanzi RE (2004). “No association between a previously reported OLR1 3’UTR polymorphism and Alzheimer’s disease in a large family sample.” J Med Genetics 41(4): 286-288.
  • Bertram L, Menon R, Mullin K, Parkinson M , Bradley M, Blacker D, Tanzi RE (2004). “PEN2 is not a genetic risk factor for Alzheimer’s disease in a large family sample”. Neurology 62(2):304-306.
  • Saunders AJ, Bertram L, Mullin K, et al. (2003). Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin. Hum Mol Genet 12: 2765-76.
  • Bertram L, Saunders AJ, Mullin K, Sampson A, Moscarillo TJ, Basset SS, Go RCP, Blacker D, Tanzi RE (2003). “No association between marker D10S1423 and Alzheimer's disease.” Mol Psychiatry 8: 571-3.
  • McQueen MB, Bertram L, Rimm EB, Blacker D, Santangelo SL (2003): A QTL “A QTL genome scan of the metabolic syndrome and its component traits.” Genetic Analysis Workshop 13, Almasy L et al, eds; BMC Genetics 4 (Suppl 1): S96.
  • Blacker D, Bertram L, Saunders J, et al. (2003) “Results of a high-resolution genome screen of 437 Alzheimer's disease families.” Hum Mol Genet 12: 23-32.
  • Tanzi RE, Bertram L (2001) “New frontiers in Alzheimer’s disease genetics.” Neuron 32:181-184.
  • Bertram L, Hayward B, Lake S, Falls K, Van Eerdewegh P, Blacker D. (2001) “Family-based tests of association in the presence of known linkage.” Genetic Epidemiology; 21(Suppl 1):S292-S297.
  • Bertram L, Guenette S, Jones J, et al. (2001) “No evidence for genetic association or linkage of the cathepsin D (CTSD) exon 2 polymorphism and Alzheimer disease.” Ann Neurol 49(1): 114-6.
  • Bertram L, Blacker D, Mullin K, Keeney D, Jones J, Basu S, Yhu S, McInnis MG, Go RC, Vekrellis K, Selkoe DJ, Saunders AJ, Tanzi RE (2000) ”Evidence for genetic linkage of Alzheimer's disease to chromosome 10q.” Science 290(5500):2302-3.
  • Bertram L, Blacker D, Crystal A, et al. (2000) “Candidate genes showing no evidence for association or linkage with Alzheimer’s disease using family-based methodologies.” Exp Gerontol 35(9-10): 1353-61.
  • Bertram L, Busch R, Spiegl M, Lautenschlager NT, Müller U, Kurz A (1998) “Paternal age is a risk factor for Alzheimer disease in the absence of a major gene.” Neurogenetics 1: 277-280.
 

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