Ausgewählte Publikationen von Prof. Dr. Paul Saftig

  • Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Häsler R, Becker C, Neurath MF, Reiß K, Saftig P, Scheller J, Rose-John S. (2010) Critical role of the disintegrin metalloproteinase ADAM17 for intestinal inflammation and regeneration in mice. J Exp Med., in press
  • Mendelson K, Swendeman S, Saftig P, Blobel CP. (2010) Stimulation of the PDGFR{beta} activates ADAM17 and promotes metalloproteinase-dependent crosstalk between the PDGFR{beta} and EGFR signaling pathways. J Biol Chem., in press
  • Kim J, Lilliehook C, Dudak A, Prox J, Saftig P, Federoff HJ, Lim ST. (2010) Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10). J Biol Chem., in press
  • Shevtsova, Z., Garrido, M., Weishaupt, J., Saftig, P., Bähr, M., Lühder, F., Kügler, S. (2010) CNS-expressed cathepsin D prevents lymphopenia in a murine model of congenital ceroid lipofuscinosis. Am. J. Pathol., 177: 271-279
  • Schröder, B., Saftig, P. (2010) Molecular insights into mechanisms of intramembrane proteolysis through signal peptide peptidase (SPP). Biochem J. 14:427(3):e1-3
  • Blanz J, Groth J, Zachos C, Wehling C, Saftig P, Schwake M. (2010) Disease-causing mutations within the lysosmal integral membrane protein type 2 (LIMP-2) reveal the nature of binding to its ligand beta-glucocerebrosidase. Hum Mol Genet.,19: 563-572
  • Schröder, B., Wrocklage, C., Hasilik, A., Saftig, P. (2010) Molecular characterisation of “Transmembrane protein 192" (TMEM192), a novel protein of the lysosomal membrane. Biol. Chem., 391: 695-704
  • Jorissen, E., Prox, J., Bernreuther, C., Weber, S., Schwanbeck, R., Serneels, L., Snellinx, A., Craessaerts, K., Ththiah, A., Tesseur, I., Bartsch, U., Weskamp, G., Blobel, C.P., Glatzel, M., de Strooper, B., Saftig, P. (2010) The disintegrin/metalloproteinase ADAM10 is essential fort he establishement of the brain cortex. J. Neurosci., 30:4833-4844
  • Arndt, V., Dick,N., Tawo,R., Dreiseidler,M., Wenzel,D.,Hesse, M.,Fürst,D.O., Saftig,P., Saint, R., Fleischmann,B.K., Hoch,M., Höhfeld, J. (2010) Chaperone-assisted selective autophagy is essential for muscle maintenance. Current Biology, 20: 143-148
  • Schneede, A., Schmidt, C.K.,Maarit Hölttä-Vuori, C., Heeren, J., Willenborg, M., Blanz, J., Domanskyy,M., Breiden,B., Brodesser, S., Landgrebe, J., Sandhoff, K., Ikonen, E., Saftig, P., Eeva-Liisa Eskelinen (2010) Role for LAMP-2 in endosomal cholesterol transport J. Cell. Mol. Med., in press
  • Hata, S., Fujishige,S. Araki, Y., Kato, N., Araseki,M., Nishimura, M., Hartmann, D., Saftig, P., Fahrenholz,F., Taniguchi,M., Urakami, K., Akatsu, H., Martins, RN, Yamamoto, K., Maeda, M., Yamamoto,T., Nakaya,T., Gandy,S., Suzuki, T. (2010) Alcadein cleavages by APP alpha-and gamma-secretases generate small peptides p3-Alcs indicating Alzheimer disease-related gamma-secretase dysfunction. J. Biol. Chem., 284:36024-36033
  • Ha, S.D., Ham, B., Mogridge, J., Saftig, P., Lin, S., Kim, S.O. (2010) Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm. J. Biol. Chem., 285: 2120-2129
  • Wilson, S., Hashamiyan, S., Clarke, L., Saftig, P., Mort, J., Dejica, V.M., Brömme, D. (2009) Glycosaminoglycan-mediated loss of Cathepsin K collagenolytic activity in MPS I contributes to osteoclast and growth plate abnormalities. Am. J. Pathol.,175:2053-2062
  • Cruz-Soto, M., Cosio, G., Jeziorski, M.C., Vargas,V., Aguilar, M., Carabez, A., Berger, P., Saftig, P., Thebault, S., de la Escalera, G.M., Clapp, C. (2009) Cathepsin D is the primary protease for the generation of the adenohypophseal vasoinhibins: Clea vage occurs within the prolactin secretory granules. Endocrinology, 150: 5446-5454
  • Bai, L., Lutgens, S.P., Herias, M.V., Saftig, P., Daemen, M., Cleutjens, K., Biessen, E.A., Heeneman, S. (2009) Cathepsin K gene disruption does not affec murine anerysm formation. Atherosclerosis, 209: 96-103
  • Bloch, L., Sineshchekova, O., Reichenbach, D., Reiss, K., Saftig, P., Kuro-o, M., Kaether, C. (2009) Klotho is a substrate for a-, b- and g-secretase. FEBS Lett.,583:3221-3224
  • Janes,P., Wimmer-Kleikamp, S., Frangakis,A., Treble, K., Griesshaber,B., Sabet, O.,Grabenbauer,M., Ting,A.,Saftig,P., Bastiaens, P., Lackmann, M. (2009) Cytoplasmic Relaxation of Active Eph Controls Ephrin Shedding by ADAM10. PLoS Biology, 7: e1000215
  • Tousseyn, T., Thathiah, A., Jorissen, E., Raemaekers, T., Konietzko, U., Reiss, K., Maes,k E., Snellinx, A., Serneels, L., Nyabi, O., Annaert, W., Weskamp, G., Blobel, C., Saftig, P., Hartmann, D., de Strooper, B. (2009) ADAM10, the rate limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed itself by ADAMs 9, -15, and g-secretase. J. Biol. Chem.,284:11738-11747
  • Cullen, V., Lindfors, M., Ng, J., Paetau, A., Swinton, E., Kolodzeij, P., Boston, H., Saftig, P., Woulfe, J., Feany, M.B., Myllykangas, L., Schlossmacher, M.G., Tyynelä, J. (2009) Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo. Molecular Brain, 2: 5
  • Le Gall, S.M., Bobe, P., Reiss, K., Horiuchi, K., Niu, X.D., Lundell, D., Gibb, D.R., Conrad, D., Saftig, P., Blobel, C.P. (2009) ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as TGFaplha, L-selectin and TNFalpha. Moll. Biol. Cell ,20:1785-1794
  • Schröder,J., Lüllmann-Rauch, R., Himmerkus, N., Pleines, I., Nieswandt,B., Orinska, Z., Koch-Nolte, F., Schröder, B., Bleich, M., Saftig, P. (2009) Deficiency of the tetraspanin CD63 associated with kidney pathology but normal platelet and lysosomal function. Mol. Biol. Cell, 29: 1083-1094
  • Wilson, SR, Peters, C., Saftig, P., Brömme, D. (2008) Cathepsin K activity dependent regulation of osteoclast actin ring formation and bone resporption. J. Biol. Chem. ,284:2584-2592
  • Reiss, K. and Saftig, P. (2009) The "A Disintegrin And Metalloproteinase" (ADAM) family of Sheddases: Physiological and cellular functions. Seminars- Cell and Dev. Biol., 20:126-137
  • Huth, T., Schmidt-Neuenfeldt, K., Rittger, A., Saftig, P., Reiss, K., Alzheimer, C. (2008) Non proteolytic effect of b-site APP-cleaving enzyme 1 (BACE1) on sodium channel function. Neurobiol. Disease, 33: 282-289
  • Pennypacker, B., Shea, M., Liu, Q., Masarachia, P., Saftig, P., Rodan, S., Rodan, G., Kimmel, D. (2008) Bone densitiy, strength, and formation in adult cathepsin K (-/-) mice. Bone, 44:199-207
  • Blanz, J., Stroobants, S., Lüllmann-Rauch, R., Morelle, W., Lüdemann, M., D´Hooge, R., Reuterwall, H., Michalski, J.C., Fogh, J., Andersson, C., Saftig, P.(2008) Reversal of peripheral and central nervous storage and ataxia after recombinant enzyme replacement therapy in alpha-mannosidosis mice . Hum. Mol. Genet., 17: 3437-3445
  • Raucci, A., Cugusi, S., Antonelli, A., Barabino, S.M., Monti, L., Bierhaus, A., Reiss, K., Saftig, P., Bianchi, M.E. (2008) A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane bound form by the sheddase a disintegrin and metalloproteinase 10 (ADAM10) FASEB J., 22: 3716-3727
  • Jabs, S., Quitsch, A., Käkelä,R., Koch, B. Tyynelä, J., Brade,H., Glatzel, M., Walkley, S., Saftig,P., Vanier, M.T., Braulke, T. (2008) Accumulation of Bis(monoacylglycero)phosphate and gangliosides in mouse models of neuronal ceroid lipofuscinosis. J. Neurochem., 106: 1415-1425
  • Schulz, B., Prüssmeyer, J., Maretzky, T., Ludwig, A., Vlobel, C.P., Saftig, P., Reiß, K. (2008) Disintegrin Metalloprotease (ADAM) 10 Regulates Endothelial Permeability and T Cell Transmigration by Proteolysis of Vascular Endothelial Cadherin Circ. Res., 102: 1192-1201
  • Samokhin, A.O., Wong, A., Saftig, P., Brömme, D. (2008)Role of cathepsin K in structural changes in brachiocephalic artery during progression of atherosclerosis in apoE-deficient mice. Atherosclerosis, 200: 58-68
  • Asagiri, M., Hirai, T.,Kunigami, T., Kamano, S., Gober, H-J., Okamoto, K., Nishikawa, K., Latz, E., Golenbock,D.T., Aoki,K., Ohya,K., Imai,K., Morishita,Y., Miyazono,K., Kato, S., Saftig,P., Takayanagi, H. (2008) Cathepsin K-Dependent Toll-like Receptor 9 Signaling Revealed in Experimental Arthritis. Science, 319:624-627
  • Berkovic, S.F., Dibbens, L.M., Oshlack, A., Silver, J.D.,Katerelos,M., Vears, D.V., Lüllmann-Rauch,R., Blanz, R., Zhang,K.W., Stankovich,J., Kalnins, R.M., Dowling,J.P., Andermann, E., Andermann,F., Faldini, E., D'Hooge, R., Vadlamudi,L., Macdonell,R.A., Hodgson,B.L., Bayly,M.A., Savige, J., Mulley, J.C., Smyth, G.K., Power, D.A., Saftig,P., Bahlo, M. (2008) Array based gene discovery with 3 unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis. Am. J. Hum. Genetics, 82:673-684
  • Maretzky, T., Scholz, F., Köten, B., Proksch, E., Saftig, P., Reiss, K. (2008) ADAM10-mediated E-cadherin release is regulated by proinflammatory cytokines and modulates keratinocyte cohesion in eczematous dermatitis. J. Invest. Dermat., 128:1737-1746
  • Reczek,D., Schwake, M., Schröder,J., Hughes,H., Blanz,J., Jin, X., Brondyk, W., Van Patten, S., Edmunds, T., Saftig, P. (2007) LIMP-2 is a receptor for lysosomal mannose 6-phosphate independent targeting of beta-glucocerebrosidase. Cell, 131:770-783
 

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