Article by Christian Haass
Alzheimer’s Disease is by far the most frequent age dependent neurodegenerative disorder and heavily threatens public health in our senescing society. Cure is desperately required, however conventional symptomatic attempts failed. In contrast, novel mechanism based therapeutic approaches are now providing strong hope that progression of Alzheimer’s disease may be slowed or even prevented. These novel therapeutic approaches are based on the identification of a variety of key enzymes, the secretases, which allow the proteolytic generation of the disease characterizing Amyloid ß-peptide.