Publikationen

Hinweis: Über die Vergabe eines Forschungspreises und von Stipendien wird Ende Mai 2019 entschieden.

Bitte vorher keine Bewerbungen einsenden!

Ausgewählte Publikationen von Prof. Dr. Manuela Neumann

  • Neumann, M., Sampathu, D.M., Kwong, L.K., Truax, A.C., Micsenyi, M.C., Chou, T.T., Bruce, J., Schuck, T., Grossman, M., Clark, C.M., et al. (2006). Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 314, 130-133.
  • Neumann, M., Mackenzie, I.R., Cairns, N.J., Boyer, P.J., Markesbery, W.R., Smith, C.D., Taylor, J.P., Kretzschmar, H.A., Kimonis, V.E., and Forman, M.S. (2007). TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations. J Neuropathol Exp Neurol 66, 152-157.
  • Cairns, N.J., Neumann, M., Bigio, E.H., Holm, I.E., Troost, D., Hatanpaa, K.J., Foong, C., White, C.L., 3rd, Schneider, J.A., Kretzschmar, H.A., et al. (2007). TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions. Am J Pathol 171, 227-240.
  • Neumann, M., Kwong, L.K., Truax, A.C., Vanmassenhove, B., Kretzschmar, H.A., Van Deerlin, V.M., Clark, C.M., Grossman, M., Miller, B.L., Trojanowski, J.Q., et al. (2007). TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions. J Neuropathol Exp Neurol 66, 177-183.
  • Roeber, S., Mackenzie, I.R., Kretzschmar, H.A., and Neumann, M. (2008). TDP-43-negative FTLD-U is a significant new clinico-pathological subtype of FTLD. Acta Neuropathol 116, 147-157.
  • Kuhnlein, P., Sperfeld, A.D., Vanmassenhove, B., Van Deerlin, V., Lee, V.M., Trojanowski, J.Q., Kretzschmar, H.A., Ludolph, A.C., and Neumann, M. (2008). Two German kindreds with familial amyotrophic lateral sclerosis due to TARDBP mutations. Arch Neurol 65, 1185-1189.
  • Neumann, M., Kwong, L.K., Lee, E.B., Kremmer, E., Flatley, A., Xu, Y., Forman, M.S., Troost, D., Kretzschmar, H.A., Trojanowski, J.Q., et al. (2009). Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies. Acta Neuropathol 117, 137-149.
  • Mackenzie, I.R., Neumann, M., Bigio, E.H., Cairns, N.J., Alafuzoff, I., Kril, J., Kovacs, G.G., Ghetti, B., Halliday, G., Holm, I.E., et al. (2009). Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations. Acta Neuropathol 117, 15-18.
  • Neumann, M., Rademakers, R., Roeber, S., Baker, M., Kretzschmar, H.A., and Mackenzie, I.R. (2009). A new subtype of frontotemporal lobar degeneration with FUS pathology. Brain 132, 2922-2931.
  • Dormann, D., Rodde, R., Edbauer, D., Bentmann, E., Fischer, I., Hruscha, A., Than, M.E., Mackenzie, I.R., Capell, A., Schmid, B., et al. (2010). ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import. EMBO J 29, 2841-2857.
  • Waibel, S., Neumann, M., Rabe, M., Meyer, T., and Ludolph, A.C. (2010). Novel missense and truncating mutations in FUS/TLS in familial ALS. Neurology 75, 815-817.
  • Mackenzie, I.R., Neumann, M., Bigio, E.H., Cairns, N.J., Alafuzoff, I., Kril, J., Kovacs, G.G., Ghetti, B., Halliday, G., Holm, I.E., et al. (2010). Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta Neuropathol 119, 1-4.
  • Mackenzie, I.R., Rademakers, R., and Neumann, M. (2010). TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia. Lancet Neurol 9, 995-1007.
  • Mackenzie, I.R., Neumann, M., Baborie, A., Sampathu, D.M., Du Plessis, D., Jaros, E., Perry, R.H., Trojanowski, J.Q., Mann, D.M., and Lee, V.M. (2011). A harmonized classification system for FTLD-TDP pathology. Acta Neuropathol 122, 111-113.
  • Neumann, M., Bentmann, E., Dormann, D., Jawaid, A., DeJesus-Hernandez, M., Ansorge, O., Roeber, S., Kretzschmar, H.A., Munoz, D.G., Kusaka, H., et al. (2011). FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations. Brain 134, 2595-2609.
  • Rademakers, R., Neumann, M., and Mackenzie, I.R. (2012). Advances in understanding the molecular basis of frontotemporal dementia. Nat Rev Neurol 8, 423-434.
  • Mackenzie, I.R., and Neumann, M. (2012). FET proteins in frontotemporal dementia and amyotrophic lateral sclerosis. Brain Res 1462, 40-43.
  • Neumann, M., Valori, C.F., Ansorge, O., Kretzschmar, H.A., Munoz, D.G., Kusaka, H., Yokota, O., Ishihara, K., Ang, L.C., Bilbao, J.M., et al. (2012). Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations. Acta Neuropathol 124, 705-716.
  • Dormann, D., Madl, T., Valori, C.F., Bentmann, E., Tahirovic, S., Abou-Ajram, C., Kremmer, E., Ansorge, O., Mackenzie, I.R., Neumann, M., et al. (2012). Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS. EMBO J 31, 4258-4275.
  • Halliday, G., Bigio, E.H., Cairns, N.J., Neumann, M., Mackenzie, I.R., and Mann, D.M. (2012). Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects. Acta Neuropathol 124, 373-382.
  • Mackenzie, I.R., Arzberger, T., Kremmer, E., Troost, D., Lorenzl, S., Mori, K., Weng, S.M., Haass, C., Kretzschmar, H.A., Edbauer, D., et al. (2013). Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations. Acta Neuropathol 126, 859-879.
  • Waibel, S., Neumann, M., Rosenbohm, A., Birve, A., Volk, A.E., Weishaupt, J.H., Meyer, T., Muller, U., Andersen, P.M., and Ludolph, A.C. (2013). Truncating mutations in FUS/TLS give rise to a more aggressive ALS-phenotype than missense mutations: a clinico-genetic study in Germany. Eur J Neurol 20, 540-546.
  • Neumann, M. (2013). Frontotemporal lobar degeneration and amyotrophic lateral sclerosis: molecular similarities and differences. Rev Neurol (Paris) 169, 793-798.
  • Ravenscroft, T.A., Baker, M.C., Rutherford, N.J., Neumann, M., Mackenzie, I.R., Josephs, K.A., Boeve, B.F., Petersen, R., Halliday, G.M., Kril, J., et al. (2013). Mutations in protein N-arginine methyltransferases are not the cause of FTLD-FUS. Neurobiol Aging 34, 2235 e2211-2233.
  • Mackenzie, I.R., Frick, P., and Neumann, M. (2014). The neuropathology associated with repeat expansions in the C9ORF72 gene. Acta Neuropathol 127, 347-357.
  • Wong, T.H., Chiu, W.Z., Breedveld, G.J., Li, K.W., Verkerk, A.J., Hondius, D., Hukema, R.K., Seelaar, H., Frick, P., Severijnen, L.A., et al. (2014). PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology. Brain 137, 1361-1373.
  • Mackenzie, I.R., Frick, P., Grasser, F.A., Gendron, T.F., Petrucelli, L., Cashman, N.R., Edbauer, D., Kremmer, E., Prudlo, J., Troost, D., et al. (2015). Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers. Acta Neuropathol 130, 845-861.
  • Suarez-Calvet, M., Neumann, M., Arzberger, T., Abou-Ajram, C., Funk, E., Hartmann, H., Edbauer, D., Kremmer, E., Gobl, C., Resch, M., et al. (2016). Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS. Acta Neuropathol 131, 587-604.
  • Mackenzie, I.R., and Neumann, M. (2016). Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies. J Neurochem 138 Suppl 1, 54-70.
  • Prudlo, J., Konig, J., Schuster, C., Kasper, E., Buttner, A., Teipel, S., and Neumann, M. (2016). TDP-43 pathology and cognition in ALS: A prospective clinicopathologic correlation study. Neurology 87, 1019-1023.
  • Mackenzie, I.R.A., and Neumann, M. (2017). Fused in Sarcoma Neuropathology in Neurodegenerative Disease. Cold Spring Harb Perspect Med 7.
  • Braak, H., Ludolph, A.C., Neumann, M., Ravits, J., and Del Tredici, K. (2017). Pathological TDP-43 changes in Betz cells differ from those in bulbar and spinal alpha-motoneurons in sporadic amyotrophic lateral sclerosis. Acta Neuropathol 133, 79-90.
  • Mackenzie, I.R., and Neumann, M. (2017). Reappraisal of TDP-43 pathology in FTLD-U subtypes. Acta Neuropathol 134, 79-96.
  • Frick, P., Sellier, C., Mackenzie, I.R.A., Cheng, C.Y., Tahraoui-Bories, J., Martinat, C., Pasterkamp, R.J., Prudlo, J., Edbauer, D., Oulad-Abdelghani, M., et al. (2018). Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers. Acta Neuropathol Commun 6, 72.
 

Unsere Webseiten verwenden Cookies zur Verbesserung der Bedienung und des Angebots sowie zur Auswertung von Webseitenbesuchen. Einzelheiten über die von uns eingesetzten Cookies und die Möglichkeit diese abzulehnen, finden Sie in unseren Datenschutzhinweisen.