Ausgewählte Publikationen

Ausgewählte Publikationen von Prof. Dr. Lichtenthaler

  • Blume T, Filser F, Jaworska A, Blain JF, König G, Moschke K, Lichtenthaler SF, Herms J (2018). BACE1 inhibitor MK-8931 alters formation but not stability of dendritic spines. Frontiers in Aging Neurosci, in press
     
  • Meinl E, Thaler FS, Lichtenthaler SF (2018). Shedding of BAFF/APRIL receptors controls B cells. Trends Immunol, in press.
     
  • Causevic M, Dominko K, Malnar M, Vidatic L, Cermak S, Pigoni M, Kuhn PH, Colombo A, Havas D, Flunkert S, McDonald J, Gunnersen JM, Hutter-Paier B, Tahirovic  S, Windisch M, Krainc D, Lichtenthaler SF, Hecimovic S (2018). BACE1 - cleavage of Sez6 and Sez6L is elevated In Niemann-Pick type C disease mouse brains. PLOS ONE 13 (7), e0200344.
     
  • Lichtenthaler SF, Lemberg M, Fluhrer R (2018). Proteolytic ectodomain shedding of membrane proteins in mammals - hardware, concepts and recent developments. EMBO J. 37, e99456.
     
  • Duernberger Y, Liu S, Riemschoss K, Paulsen L, Bester R, Kuhn PH, Schölling M, Lichtenthaler SF, Vorberg I (2018). Prion replication in the mammalian cytosol: Functional regions within a prion domain driving induction, propagation and inheritance. Mol Cell Biol, in press.
     
  • Herber J, Njavro J, Feederle R, Schepers U, Müller UC, Bräse S, Müller SA, Lichtenthaler SF (2018). Click chemistry-mediated biotinylation reveals a function for the protease BACE1 in modulating the neuronal surface glycoproteome. Molecular and Cellular Proteomics, in press.
     
  • Zellner A, Scharrer E, Arzberger T, Oka C, Domenga-Denier V, Joutel A, Lichtenthaler SF, Müller SA, Dichgans M, Haffner C (2018). CADASIL brain vessels show a HTRA1 loss-of-function profile. Acta Neuropathologica 136, 111-125.
     
  • Hartlage-Rübsamen M, Bluhm A, Piechotta A, Rahfeld JU, Demuth HU, Lues I, Kuhn PH, Lichtenthaler SF, Rossner S, Höfling C (2018). Immunohistochemical evidence from APP-transgenic mice for glutaminyl cyclase as drug target to diminish pE-Abeta formation. Molecules 23, 924.
     
  • Voytyuk I, Müller SA, Herber J, Snellinx A, Moechars D, van Loo G, Lichtenthaler SF, De Strooper B. (2018). BACE2 distribution in major brain cell types and identification of novel substrates. Life Science Alliance 1,1, e201800026.
     
  • Brummer T, Pigoni M, Rossello A, Wang H, Noy PJ, Tomlinson MG, Blobel CP, Lichtenthaler SF (2018). The Metalloprotease ADAM10 (a Disintegrin and Metalloprotease 10)  undergoes rapid, postlysis autocatalytic degradation. FASEB J. 32(7), 3560-3573.
     
  • Colombo A, Hsia HE, Wang M, Kuhn PH, Brill MS, Canevazzi P, Feederle R, Taveggia C, Misgeld Th, Lichtenthaler SF (2018). Non-cell-autonomous function of DR6 in Schwann cell proliferation. EMBO J. 37, e97390.
     
  • Schlepckow K, Kleinberger G, Fukumori A, Lichtenthaler SF, Steiner H, Haass C (2017). An Alzheimer associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function. EMBO Mol Med 9, 1356-1365.
     
  • Bruch J, Xu H, Rösler TW, De Andrade A, Kuhn PH, Lichtenthaler SF, Arzberger T, Winklhofer KF, Müller U, Höglinger GU. (2017). PERK activation mitigates tau pathology in vitro and in vivo. EMBO Mol Med 9, 371-384.
     
  • Zhu K, Xiang X, Filser S, Dorostkar MM, Crux S, Marinković P, Neumann U, Shimshek DR, Rammes G, Haass C, Lichtenthaler SF, Gunnersen JM, Herms J (2018). BACE1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6. Biol Psychiatry 83, 428-437.
     
  • Baranger K, Bonnet AE, Girard SD, Paumier JM, Garcia-Gonzalez L, Elmanaa W, Bernard A, Charrat E, Stephan D, Bauer C, Moschke K, Lichtenthaler SF, Roman FS , Checler F, Khrestchatisky M, Rivera S (2017). MT5-MMP Promotes Alzheimer’s Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro. Frontiers Mol Neurosci 9, 163.
     
  • Pigoni M, Gunnersen JM, Lichtenthaler SF (2017). Seizure-6 proteins highlight BACE1 functions in neurobiology. Oncotarget 8, 7214-7215.
     
  • Scilabra SD, Yamamoto K, Pigoni M, Sakamoto K, Müller SA, Papadopoulou A, Lichtenthaler SF, Troeberg L, Nagase H, Kadomatsu K. (2017). Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue. Matrix Biol 59, 69-79.
     
  • Serdaroglu A, Mueller S, Schepers U, Bräse S, Weichert W, Lichtenthaler SF, Kuhn PH (2017). An optimized version of the Secretome Protein Enrichment with Click Sugars (SPECS) method leads to enhanced coverage of the secretome. Proteomics 17, 1600423.
     
  • Müller SA, Scilabra SD, Lichtenthaler SF (2016). Proteomic Substrate Identification for Membrane Proteases in the Brain. Frontiers in Mol Neurosci 9, 96.
     
  • Pigoni M, Wanngren J, Kuhn PH, Munro KM, Gunnersen JM, Takeshima H, Feederle R, Voytyuk I, De Strooper B, Levasseur MD, Hrupka BJ, Müller SA, Lichtenthaler SF (2016). Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons. Mol Neurodegen 11, 67.
     
  • Biella G, Fusco F, Nardo E, Bernocchi O, Colombo A, Lichtenthaler SF, Forloni G, Albani D. (2016). Sirtuin 2 Inhibition Improves Cognitive Performance and Acts on Amyloid- Protein Precursor Processing in Two Alzheimer’s Disease Mouse Models. J Alzheimers Dis 53, 1193-1207.
     
  • Munro KM, Nash A, Pigoni M, Lichtenthaler SF, Gunnersen JM (2016). Functions of the Alzheimer’s disease protease BACE1 at the synapse in the central nervous system.  J Mol Neurosci 60, 305-315.
     
  • Höfling C, Morawski M, Zeitschel U, Moschke K, Canneva F, von Hörsten S, Jäger C, Kremmer E, Roßner S, Lichtenthaler SF, Kuhn PH (2016). Differential transgene expression patterns in Alzheimer mouse models revealed by novel human APP-specific antibodies. Aging Cell 15, 953-963.
     
  • Kretner B, Trambauer J, Fukumori A, Mielke J, Kuhn PH, Kremmer E, Giese A, Lichtenthaler SF, Haass C, Arzberger T, Steiner H (2016). Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease. EMBO Mol Med 8, 458-465.
     
  • Schönherr C, Bien J, Isbert S, Wichert R, Prox J, Altmeppen H, Kumar S, Walter J, Lichtenthaler SF, Weggen S, Glatzel M, Becker-Pauly C, Pietrzik CU (2016). Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site. 
     
  • Kuhn PH, Colombo AV, Schusser B, Dreymueller D, Wetzel S, Schepers U, Herber J, Ludwig A, Kremmer E, Montag D, Müller U, Schweizer M, Saftig P, Bräse S, Lichtenthaler SF (2016). Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function. eLife 5, e12748.
     
  • Barão S, Moechars D, Lichtenthaler SF, De Strooper B. (2016). BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease. Trends in Neurosci 39, 158-169.
     
  • Baranger K, Marchalant Y, Bonnet AE, Crouzin N, Carrete A, Paumier JM, Py NA, Bernard A, Bauer C, Charrat E, Moschke K, Seiki M, Vignes M, Lichtenthaler SF, Checler F, Khrestchatisky M, Rivera S. (2016). MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease. Cell Mol Life Sci 73, 217-236.
     
  • Schulz AM, Stutte S, Hogl S, Dudziak D, Leroy C, Forné I, Imhof A, Müller SA, Brakebusch CH, Lichtenthaler SF, Brocker T (2015). Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells. J Cell Biol 211, 553-567.
     
  • Saftig P, Lichtenthaler SF (2015). The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain. Prog Neurobiol 135, 1-20.
     
  • Li S, Dislich B, Brakebusch CH, Lichtenthaler SF, Brocker T (2015). Control of Homeostasis and Dendritic Cell Survival by the GTPase RhoA. J Immunol 195, 4244-4256.
     
  • Lichtenthaler SF, O’Hara BF, Blobel CP (2015). iRhoms in the brain – a new frontier? Cell Cycle 14, 3003-3004.
     
  • Dislich B, Wohlrab F, Bachhuber T, Mueller S, Kuhn PH, Hogl S, Meyer-Luehmann M, Lichtenthaler SF (2015). Label-free quantitative proteomics of mouse cerebrospinal fluid detects BACE1 protease substrates in vivo. Mol Cell Proteomics 14, 2550-2563.
     
  • Laurent SA, Hoffmann FS, Kuhn PH, Cheng Q, Chu Y, Schmidt-Supprian M, Hauck SM, Schuh E, Krumbholz M, Rübsamen H, Wanngren J, Khademi M, Olsson T, Alexander T, Hiepe F, Pfister HW, Weber F, Jenne D, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E (2015). γ-secretase directly sheds the survival receptor BCMA from plasma cells. Nat Communic 6, 7333.
     
  • Kuhn PH, Voss M, Haug-Kröper M, Schröder B, Schepers U, Bräse S, Haass C, Lichtenthaler SF*, Fluhrer R* (2015). Secretome analysis identifies novel signal Peptide peptidase-like 3 (sppl3) substrates and reveals a role of sppl3 in multiple Golgi glycosylation pathways. Mol Cell Proteomics 14, 1584-1592. *Senior authors: Lichtenthaler and Fluhrer.
     
  • Hoffmann FS, Kuhn PH, Laurent SA, Hauck SM, Berer K, Wendlinger SA, Krumbholz M, Khademi M, Olsson T, Dreyling M, Pfister HW, Alexander T, Hiepe F, Kümpfel T, Crawford HC, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E (2015). The Immunoregulator Soluble TACI Is Released by ADAM10 and Reflects B Cell Activation in Autoimmunity. J Immunol 194, 542-552.
     
  • Cox CJ, Choudhry F, Peacey E, Perkinton MS, Richardson JC, Howlett DR, Lichtenthaler SF, Francis PT and Williams RJ (2015). Dietary (-) -epicatechin as a potent inhibitor of bg – secretase amyloid precursor protein processing. Neurobiol Aging 36, 178-187.
     
  • Voss M, Künzel U, Higel F, Kuhn PH, Colombo A, Fukumori A, Haug-Kröper M, Klier B, Grammer G, Seidl A, Schröder B, Obst R, Steiner H, Lichtenthaler SF, Haass C, Fluhrer R (2014). Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation. EMBO J 33, 2890-2905.
     
  • Vassar R, Kuhn PH, Haass C, Kennedy ME, Rajendran L, Wong PC, Lichtenthaler SF (2014). Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects. J Neurochem 130, 4-28.
     
  • Schwenk BM, Lang CM, Hogl S, Orozco D, Tahirovic S, Rentzsch K, Lichtenthaler SF, Hoogenraad CC, Capell A, Haass C, Edbauer D (2014). TMEM106B and MAP6 control dendritic trafficking of lysosomes. EMBO J 33,450-467.
     
  • Ohno M, Hiraoka Y, Lichtenthaler SF, Nishi K, Saijo S, Matsuoka T, Tomimoto H, Araki W, Takahashi R, Kita T, Kimura T, Nishi E (2014). Nardilysin prevents amyloid plaque formation by enhancing alpha-secretase activity in an Alzheimer's disease mouse model. Neurobiol Aging 35, 213-222.
     
  • Hachmeister M, Bobowski KD, Hogl S, Dislich B, Fukumori A, Eggert C, Mack B, Kremling H, Sarrach S, Coscia F, Zimmermann W, Steiner H, Lichtenthaler SF, Gires O (2013). Regulated Intramembrane Proteolysis and Degradation of Murine Epithelial Cell Adhesion Molecule mEpCAM. PLOS One 8, e71836.
     
  • Taverna M, Straub T, Hampel H, Rujescu D, Lichtenthaler SF (2013). A new sandwich immunoassay for detection of the alpha-secretase cleaved, soluble amyloid precursor protein in cerebrospinal fluid and serum. J Alzheimer’s Disease 37, 667-678.
     
  • Ivankov D, Bogatyreva N, Hönigschmid P, Dislich B, Hogl S, Kuhn PH, Frishman D, Lichtenthaler SF (2013). QARIP: a web server for quantitative proteomic analysis of regulated intramembrane proteolysis. Nucl Acids Res 41, W459-W464.
     
  • Misgeld T, Lichtenthaler SF, Dichgans M (2013). Between novel genetic discoveries and large randomized trials; neurological research in the era of systems medicine. EMBO Rep 14, 489-492.
     
  • Fleck C, van Bebber F, Colombo A, Galante C, Schwenk BM, Rabe L, Hampel H, Novak B, Kremmer E, Tahirovic S, Edbauer D, Lichtenthaler SF, Schmid B, Willem M, Haass C (2013). Dual Cleavage of Neuregulin 1 Type III by BACE1 and ADAM17 Liberates Its EGF-Like Domain and Allows Paracrine Signaling. J Neurosci 33, 7856-7869.
     
  • Tesseur I, Pimenova AA, Lo AC, Ciesielska M, Lichtenthaler SF, De Maeyer JH, Schuurkes JA, D'Hooge R, De Strooper B (2013). Chronic 5-HT4 receptor activation decreases Aβ production and deposition in hAPP/PS1 mice. Neurobiol Aging 34, 1779-1789.
     
  • Hofmann JP, Denner P, Nussbaum-Krammer C, Kuhn PH, Suhre MH, Scheibel T, Lichtenthaler SF, Schätzl HM, Bano D, Vorberg IM (2013). Cell-to-cell propagation of infectious cytosolic protein aggregates. Proc Natl Acad Sci U S A 110, 5951-5956.
     
  • Hogl S, van Bebber F, Dislich B, Kuhn PH, Haass C, Schmid B, Lichtenthaler SF (2013). Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Proteomics 13, 1519-1527.
     
  • Schmid B, Hruscha A, Hogl S, Banzhaf-Strathmann J, Strecker K, van der Zee J, Teucke M, Eimer S, Hegermann J, Kittelmann M, Kremmer E, Cruts M, Solchenberger B, Hasenkamp L, van Bebber F, van Broeckhoven C, Edbauer C, Lichtenthaler SF, Haass C (2013). Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth. Proc Natl Acad Sci USA 110, 4986-4991.
     
  • Müller-Rischart AK, Pilsl A, Beaudette P, Patra M, Hadian K, Funke M, Augustin R, Deinlein A, Schweimer C, Kuhn PH, Lichtenthaler SF, Motori E, Hrelia S, Wurst W, Trümbach D, Langer T, Krappmann D, Dittmar G, Tatzelt J, Winklhofer KF (2013). The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO. Mol Cell 49, 908-921.
     
  • Lichtenthaler SF (2013). iRhom2 takes control of rheumatoid arthritis. J Clin Invest 123, 560-562.
     
  • Kretner B, Fukumori A, Kuhn PH, Perez-Revuelta BI, Lichtenthaler SF, Haass C, Steiner H, (2013). Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase. J Neurochem 125, 144-156.
     
  • Cochet M, Donneger R, Cassier E, Gaven F, Lichtenthaler SF, Marin P, Bockaert J, Dumuis A, Claeysen S (2013). 5-HT4 Receptors Constitutively Promote the Non-Amyloidogenic Pathway of APP Cleavage and Interact with ADAM10. ACS Chemical Neuroscience 4, 130-140.
     
  • Colombo A, Wang H, Kuhn PH, Page R, Kremmer E, Dempsey PJ, Crawford HC, Lichtenthaler SF (2013). Constitutive a- and b-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines. Neurobiol Dis 49, 137-147.
     
  • Voss M, Fukumori A, Kuhn PH, Künzel U, Klier B, Grammer G, Haug-Kröper M, Kremmer E, Lichtenthaler SF, Steiner H, Schröder B, Haass C, Fluhrer R (2012). Foamy virus envelope protein is a substrate for signal peptide peptidase like-3 (SPPL3). J Biol Chem 287, 43401-43409.
     
  • Page RM, Münch A, Horn T, Kuhn PH, Colombo A, Reiner O, Boutros M, Steiner H*, Lichtenthaler SF*, Haass C* (2012). Loss of PAFA1B2 reduces Abeta generation by promoting the degradation of APP C-terminal fragments. J Neurosci 32, 18204-18214. *Senior authors: Steiner, Lichtenthaler and Haass.
     
  • Kuhn PH, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers S, Imhof A, Hoffmeister A, Haass C, Roßner S, Bräse S, Lichtenthaler SF (2012). Secretome Protein Enrichment with Click Sugars Identifies Physiological Substrates of the Alzheimer Protease BACE1 in Primary Neurons. EMBO J 31, 3157-3168.
     
  • Dislich B, Lichtenthaler SF (2012). The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and Beyond. Front Physiol 3, 8.
     
  • Augustin R, Endres K, Reinhardt S, Kuhn PH, Lichtenthaler SF, Hansen J, Wurst W, Trümbach D (2012). Computational identification and experimental validation of microRNAs binding to the Alzheimer related gene ADAM10. BMC Med Genet 13, 35.
     
  • Lichtenthaler SF (2012). Cell Biology: Sheddase Gets Guidance. Science 335, 179-180.
     
  • Lichtenthaler SF (2012). Alpha-Secretase Cleavage of the Amyloid Precursor Protein: Proteolysis Regulated by Signaling Pathways and Protein Trafficking. Curr Alzheimer Res 9, 165-177.
     
  • Moss ML, Powell G, Miller MA, Bin Q, Sang QX, De Strooper B, Tesseur I, Lichtenthaler SF, Taverna M, Zhong JL, Dingwall C, Ferdous T, Schlomann U, Zhou P, Griffith L, Lauffenberger D, Petrovich R, Bartsch JW (2011). ADAM9 inhibition increases membrane activity of ADAM10 and controls alpha-secretase processing of amyloid precursor protein. J Biol Chem 286, 40443-40451.
     
  • Hogl S, Kuhn PH, Colombo A, Lichtenthaler SF (2011). Determination of the Proteolytic Cleavage Sites of the Amyloid Precursor-Like Protein 2 by the Proteases ADAM10, BACE1 and γ-Secretase. PLOS One 6, e21337.
     
  • Lichtenthaler SF, Haass C, Steiner H (2011). Regulated Intramembrane Proteolysis - Lessons from Amyloid Precursor Protein Processing. J Neurochem 117, 779-796.
     
  • Augustin R, Lichtenthaler SF, Greef M, Hansen J, Wurst W and Trümbach D (2011). Bioinformatics identification of modules of transcription factor binding sites in Alzheimer’s disease related genes by in silico promoter analysis and microarrays. International Journal of Alzheimer’s disease 2011, 154325.
     
  • Peterziel H, Sackmann T, Strelau J, Kuhn PH, Lichtenthaler SF, Marom K, Klar A and Unsicker K (2011). F-spondin regulates neuronal survival through activation of disabled-1 in the chicken ciliary ganglion. Mol Cell Neuroscience 46, 483-497.
     
  • Dislich B, Than ME, Lichtenthaler SF (2011). Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33. Biochem J 433, 75-83.
     
  • Lichtenthaler SF (2011). Alpha-Secretase in Alzheimer’s Disease: Molecular Identity, Regulation and Therapeutic Potential. J Neurochem 116, 10-21.
     
  • Lichtenthaler SF (2011). ADAM10 – potential „molecular scissors“ for the treatment of Alzheimer’s disease. Future Neurology 6, 1-4.
     
  • Kuhn PH, Wang H, Dislich B, Colombo A, Zeitschel U, Ellwart JW, Kremmer E, Roßner S, Lichtenthaler SF (2010). ADAM10 is the Physiologically Relevant, Constitutive Alpha-Secretase of the Amyloid Precursor Protein in Primary Neurons. EMBO J 29, 3020-3032.
     
  • Dettmer U, Kuhn PH, Abou-Ajram C, Lichtenthaler SF, Krueger M, Kremmer E, Haass C, Haffner C. (2010). The transmembrane protein 147 (TMEM147) is a novel component of the nicalin-nomo protein complex. J Biol Chem 285, 26174-26181.
     
  • Mitterreiter S, Page RM, Kamp F, Hopson J, Winkler E, Ha HR, Hamid R, Herms J, Mayer TU, Nelson DJ, Steiner H, Stahl T, Zeitschel U, Rossner S, Haass C, Lichtenthaler SF (2010). Bepridil and Amiodarone Simultaneously Target the Alzheimer’s Disease beta- and gamma-Secretase via Distinct Mechanisms. J Neurosci 30, 8974-8983.
     
  • Malnar M, Kosicek M, Mitterreiter S, Omerbasic D, Lichtenthaler SF Goate A, Hecimovic S (2010). Niemann Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the beta-secretase pathway. Biochim Biophys Acta 1802, 682-691.
     
  • Ullrich S, Münch A, Neumann S, Kremmer E, Tatzelt J, Lichtenthaler SF (2010). The Novel Membrane Protein TMEM59 Modulates Complex Glycosylation, Cell Surface Expression and Secretion of the Amyloid Precursor Protein. J Biol Chem 285, 20664-20674.
     
  • Lammich S, Buell D, Zilow S, Ludwig AK, Nuscher B, Lichtenthaler SF, Prinzen C, Fahrenholz F, Haass C (2010). Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region. J Biol Chem 285, 15753-15760.
     
  • Leuchtenberger S, Maler J, Czirr E, Ness J, Lichtenthaler SF, Esselmann H, Pietrzik CU, Wiltfang J, Weggen S (2009). Nonsteroidal anti-inflammatory drugs and ectodomain shedding of the amyloid precursor protein. Neurodegen Dis 6, 1-8.
     
  • O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, Hebert SS, De Strooper B, Haass C, Bennett DA, Vassar R (2008). Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron 60, 988-1009.
     
  • Heiseke A, Schöbel S, Lichtenthaler SF, Vorberg I, Groschup MH, Kretzschmar H, Schatzl HM, Nunziante M (2008). The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding. Traffic 9, 1116-1129.
     
  • Schöbel S, Neumann S, Hertweck M, Dislich B, Kuhn PH, Kremmer E, Seed B, Baumeister R, Haass C, Lichtenthaler SF (2008). A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein. J Biol Chem 283, 14257-14268.
     
  • Lichtenthaler SF, Steiner H (2007). Sheddases and intramembrane-cleaving proteases: RIPpers of the membrane. Symposium on regulated intramembrane proteolysis. EMBO Rep 8, 537-541.
     
  • Kuhn PH, Marjaux E, Imhof A, De Strooper B, Haass C, Lichtenthaler SF (2007). Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase. J Biol Chem 282, 11982-11995.
     
  • Schöbel S, Neumann S, Seed B, Lichtenthaler SF (2006). Expression cloning screen for modifiers of amyloid precursor protein shedding. Int J Dev Neurosci 24, 141-148.
     
  • Neumann S, Schobel S, Jager S, Trautwein A, Haass C, Pietrzik CU, Lichtenthaler SF (2006). Amyloid Precursor-like Protein 1 Influences Endocytosis and Proteolytic Processing of the Amyloid Precursor Protein. J Biol Chem 281, 7583-7594.
     
  • Naus S, Reipschlager S, Wildeboer D, Lichtenthaler SF, Mitterreiter S, Guan Z, Moss ML, Bartsch JW (2006). Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8. Biol Chem 387, 337-346.
     
  • Friedmann E, Hauben E, Maylandt K, Schleeger S, Vreugde S, Lichtenthaler SF, Kuhn PH, Stauffer D, Rovelli G, Martoglio B (2006). SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production. Nat Cell Biol 8, 843-848.
     
  • Rossner S, Sastre M, Bourne K, Lichtenthaler SF (2006). Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease. Prog Neurobiol 79, 95-111.
     
  • von Arnim CA, Spoelgen R, Peltan ID, Deng M, Courchesne S, Koker M, Matsui T, Kowa H, Lichtenthaler SF, Irizarry MC, Hyman BT (2006). GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing. J Neurosci 26, 9913-9922.
     
  • Lichtenthaler SF (2006). Ectodomain shedding of the amyloid precursor protein: cellular control mechanisms and novel modifiers. Neurodegen Dis 3, 262-269.
     
  • Ting A, Lichtenthaler S, Xavier R, Na SY, Rabizadeh S, Holmes T, Seed B (2005). Large-scale screens for cDNAs with in vivo activity. Novartis Found Symp 267, 219-229.
     
  • Westmeyer GG, Willem M, Lichtenthaler SF, Lurman G, Multhaup G, Assfalg-Machleidt I, Reiss K, Saftig P, Haass C (2004). Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme. J Biol Chem 279, 53205-53212.
     
  • Lammich S, Schobel S, Zimmer AK, Lichtenthaler SF*, Haass C* (2004). Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region. EMBO Rep 5, 620-625. *SENIOR AUTHORS: Lichtenthaler and Haass
     
  • Lichtenthaler SF, Haass C (2004). Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model. J Clin Invest 113, 1384-1387.
     
  • Lichtenthaler SF, Dominguez DI, Westmeyer GG, Reiss K, Haass C, Saftig P, De Strooper B, Seed B (2003). The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1. J Biol Chem 278, 48713-48719.
     
  • Grimm HS, Beher D, Lichtenthaler SF, Shearman MS, Beyreuther K, Hartmann T (2003). gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta. J Biol Chem 278, 13077-13085.
     
  • Grziwa B, Grimm MO, Masters CL, Beyreuther K, Hartmann T, Lichtenthaler SF (2003). The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted. J Biol Chem 278, 6803-6808.
     
  • Rutten BP, Wirths O, Van de Berg WD, Lichtenthaler SF, Vehoff J, Steinbusch HW, Korr H, Beyreuther K, Multhaup G, Bayer TA, Schmitz C (2003). No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment. Neurobiol Dis 12, 110-120.
     
  • Lichtenthaler SF, Beher D, Grimm HS, Wang R, Shearman MS, Masters CL, Beyreuther K (2002). The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain. Proc Natl Acad Sci USA 99, 1365-1370.
     
  • Lichtenthaler SF, Multhaup G, Masters CL, Beyreuther K (1999). A novel substrate for analyzing Alzheimer's disease gamma-secretase. FEBS Lett 453, 288-292.
     
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