Publikationen

Ausgewählte Publikationen von Prof. Dr. Thomas Misgeld

  • Colombo A., Hsia H., Wang M., Kuhn P., Brill, M.S., Canevazzi P., Feederle R., Taveggia C., Misgeld T. & Lichtenthaler S. (2018) Non-cell autonomous function of DR6 in Schwann cell proliferation.
    EMBO J. (in press)
  • Misgeld T. & Schwarz T. (2017) Mitostasis in neurons: Maintaining mitochondria in an extended cellular architecture.
    Neuron, accepted, NEURON-D-17-01362R1
  • Akassoglou K., Merlini M., Rafalski V., Real R., Liang L., Jin Y., Dougherty S., DePaola V., Linden D., Misgeld T.*, & Zheng B. (2017) In vivo imaging of CNS injury and disease.
    J Neurosci, accepted, JN-SY-1826-17R1 (* equal senior author).
  • Engerer P., Suzuki S.C., Yoshimatsu T., Chapouton P., Obeng N., Odermatt B., Williams P.R., Misgeld T.*, & Godinho L.* (2017)  Uncoupling of neurogenesis and differentiation during retinal development.  
    EMBO Journal ;36:1134-46 (* equal senior author).
  • Mazaheri F., Snaidero N., Kleinberger G., Madore C., Daria A., Werner G., Krasemann S., Capell A., Trumbach D., Wurst W., Brunner B., Bultmann S., Tahirovic S., Kerschensteiner M., Misgeld T., Butovsky O. & Haass C. (2017). TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.
    EMBO Reports 18, p1186-98
  • Heink S., Yogev N., Garbers C., Gasperi C., Herwerth M., Husterer V, Bartsch H.S., Sotlar K., Krebs S., Blum H., Hemmer B., Misgeld T., Hidalgo J., Oukka M., Rose-John S., Schmidt-Supprian M., Waisman A. & Korn T. (2017) Dendritic cells are non-redundant sources of IL-6 for the priming of pathogenic Th17 cells due to a novel mode of IL-6 signalling.
    Nature Immunology, 18, p74-85.
  • Brill M.S., Kleele T., Ruschkies L., Wang M., Marahori N.A., Reuter M., Hausrat T.J., Weigand E., Fisher M., Ahles A., Engelhardt S., Bishop D.L., Kneussel M. & Misgeld T. (2016) Branch-specific microtubule destabilization mediates axon branch loss during neuromuscular synapse elimination.
    Neuron, 92, p.845-56.
  • Romanelli E., Merkler D., Mezydlo A., Weil M.T., Weber M.S., Nikić I., Potz S., Meinl E., Matznick F.E.H., Kreutzfeldt M., Ghanem A., Conzelmann K.K., Metz I., Brück W., Routh M., Simons M., Bishop D., Misgeld T.* & Kerschensteiner M. (2016) Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its model.
    Nature Communications, 7:13275 (* equal senior author).
  • Engerer P., Fecher C. & Misgeld T. (2016) Super-resolution microscopy writ large.
    Nature Biotechnology 34, p928-30.
  • Plucińska G. & Misgeld T. (2016) Imaging of neuronal mitochondria in situ.
    Current Opinion in Neurobiology 39, p152-63.
  • Herwerth M., Kalluri S.R., Srivastava R., Kleele T., Kenet S., Illes Z., Merkler D., Bennett J.L., Misgeld T.* & Hemmer B. (2016) In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology.
    Annals of Neurology 79, p794–805 (* equal senior author).
  • Bert B., Chmielewska J., Bergmann S., Busch M., Driever W., Finger-Baier K., Hößler J., Köhler A., Leich N., Misgeld T., Nöldner T., Reiher A., Schartl M., Seebach-Sproedt A., Thumberger T., Schönfelder G. & Grune B. (2016) Considerations for a European animal welfare standard to evaluate adverse phenotypes in teleost fish.
    EMBO Journal 35, p1151-4
  • Fujikawa Y., Roma L.P. Sobotta M.C., Rose A.J., Diaz M.B., Locatelli G., Breckwoldt M.O., Misgeld T., Kerschensteiner M., Herzig S., Müller-Decker K. & Dick T.P. (2016) Mouse redox histology using genetically encoded probes.
    ScienceSignaling 9, pp. rs1
  • Breckwoldt M.O., Wittmann C., Misgeld T., Kerschensteiner M. & Grabher C. (2015) Redox imaging using genetically encoded redox indicators in zebrafish and mice.
    Biological Chemistry 396, p511-22
  • Held K,, Bhonsle-Deeng L., Siewert K., Sato W., Beltrán E., Schmidt S., Rühl G., Ng J.K., Engerer P., Moser M., Klinkert W.E., Babbe H., Misgeld T., Wekerle H., Laplaud D.A., Hohlfeld R. & Dornmair K. (2015) αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell-related features.
    Neurol Neuroimmunol Neuroinflamm. 2, e107.
  • Sorbara C.D., Wagner N.E., Ladwig A., Nikic I., Merkler D., Kleele T., Marinkovic P., Godinho L., Bareyre F.M., Bishop D., Misgeld T.* & Kerschensteiner M. (2014) Pervasive axonal transport deficits in multiple sclerosis models.
    Neuron
    84, p1183-90 (* equal senior author)
  • Williams P.R., Marincu B.N., Sorbara C.D., Mahler C.F., Schumacher A.-M., Griesbeck O., Kerschensteiner M. & Misgeld T. (2014) A recoverable state of axon injury persists for hours after spinal cord contusion in vivo.
    Nature Communications 5, p5683.
  • Paquet D., Plucinska G. & Misgeld T. (2014) In vivo imaging of mitochondria in intact zebrafish larvae.
    Methods in Enzymology 547, p151-64.
  • Bishop D., Nikić I., Kerschensteiner M. & Misgeld T. (2014) The use of a laser for correlating light and electron microscopic images in thick tissue specimens.
    Methods in Cell Biology 124, p323-37.
  • Kleele T., Marinković P., Wiliams P.R., Brill M., Stern S., Weigand E.E., Engerer P., Naumann R., Hartmann J., Karl R.M., Bradke F., Bishop D., Herms J., Konnerth A., Kerschensteiner M., Godinho L. & Misgeld T. (2014) An assay to image neuronal microtubule dynamics in mice.
    Nature Communications 5, p4827.
  • Simons M., Misgeld T.* & Kerschensteiner M. (2014) A unified cell biological perspective on axon-myelin injury.
    J Cell Biol 206, p335-45 (* co-corresponding author).
  • Hartmann J., Karl R.M., Adelsberger H., Brill M.S., Rühlmann C., Ansel A., Sakimura K., Baba Y., Kurosaki T., Misgeld T. & Konnerth A. (2014) STIM1 is essential for mGluR1/TRPC3-mediated synaptic function in central neurons.
    Neuron 8, p635-44.
  • Breckwoldt M.O., Pfister F., Bradley P.M., Marinkovic P., Williams P.W., Brill M.S., Plomer B., Schmalz A., St Clair D.K., Naumann R., Griesbeck O., Schwarzländer M., Godinho L., Bareyre F.M., Dick T.P., Kerschensteiner M. & Misgeld T. (2014) Multi-parametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo.
    Nature Medicine 20, p555-60.
  • Wang K., Milkie D., Saxena A., Engerer P., Misgeld T., Bronner M., Mumm J., and Betzig E. (2014) Rapid adaptive optical recovery of optimal resolution over large multicellular volumes.
    Nature Methods11, p625-8.
  • Mar F.M., Simões A.R.,  Leite S., Morgado M.M., Santos T.E., Teixeira C.A., Misgeld T. & Sousa M.M. (2014) A global increase of axonal transport is elicited in central axons following a peripheral conditioning lesion.
    Journal of Neuroscience 34, p5965-70.
  • Pinschewer D.A., Bergthaler A., Kreutzfeldt M., Fernandez M., Brück W., Steinbach K., Vorm K., Coras R., Blümcke I., Bonilla W.V., Misgeld T., Kerschensteiner M. & Merkler D. (2013) Interferon-γ receptor – STAT1 signaling in neurons accounts for CD8+ T cell-mediated dendrite and synapse loss in inflammatory central nervous system disease.
    Journal of Experimental Medicine 210, p2087-103.
  • Misgeld T., Lichtenthaler S.F. & Dichgans M. (2013) Between novel genetic discoveries and large randomized trials; neurological research in the era of systems medicine.
    EMBO Reports 14, p489-92.
  • Romanelli E., Sorbara C.D., Nikić I., Dagkalis A., Misgeld T. & Kerschensteiner M. (2013) Cellular, subcellular and functional in vivo labeling of the spinal cord using vital dyes.
    Nature Protocols 8, p481-90.
  • Brill M.S., Marinković P. & Misgeld T. (2013) Sequential photo-bleaching to delineate single Schwann cells at the neuromuscular junction.
    JOVE 71, e4460.
  • Plucińska G., Paquet D., Hruscha A., Godinho L., Haass C., Schmid B. & Misgeld T. (2012) In vivo imaging of disease-related mitochondrial dynamics in a vertebrate model system.
    Journal of Neuroscience 32, p16203-12.
  • Marinković P., Reuter M.S., Brill M.S., Godinho L., Kerschensteiner M. & Misgeld T. (2012) Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis.
    PNAS 109, p4296-301.
  • Sorbara C., Misgeld T. & Kerschensteiner M. (2012) In vivo imaging of the diseased nervous system: an update.
    Curr Pharm Des. 18, p4465-70.
  • Gilley J., Seereeram A., Ando K., Mosely S., Andrews S., Kerschensteiner M., Misgeld T., Brion J.P., Anderton B., Hanger D.P. & Coleman MP. (2012) Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a "P301L" tau knockin mouse.
    NeurobiolAging 33, p621.e1-15.
  • Bishop D., Nikic I., Brinkoetter M., Knecht S., Potz S., Kerschensteiner M. & Misgeld T. (2011) Near-infrared branding efficiently correlates light and electron microscopy.
    Nature Methods8, p568-70.
  • Brill M.S., Lichtman J.W., Thompson W., Zuo Y. & Misgeld T. (2011) Spatial constraints dictate glial territories at murine neuromuscular junctions.
    J Cell Biol 195, p293-30.
  • Nikić I., Merkler D., Sorbara C., Brinkoetter M., Kreutzfeldt M., Bareyre F.M., Brück W., Bishop D., Misgeld T.* & Kerschensteiner M. (2011) A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis.
    Nature Medicine 17, p495-9. (* equal senior author)
  • Bareyre F.M., Garzorz N., Lang C., Misgeld T., Büning H. & Kerschensteiner M. (2011) In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration.
    PNAS 108, p6282-7.
  • Misgeld T. (2011) Lost in elimination: mechanisms of axonal loss.
    e-Neuroforum 2, p21-34.
  • Fieni F., Parkar A., Misgeld T., Kerschensteiner M., Lichtman J.W., Pasinelli P. & Trotti D. (2010) Voltage-dependent inwardly rectifying potassium conductance in the outer membrane of neuronal mitochondria.
    J Biol Chem 28, p27411-7.
  • Adalbert R., Nogradi A., Babetto E., Janeckova L., Walker S.A., Kerschensteiner M., Misgeld T. & Coleman M.P. (2009) Severely dystrophic axons at amyloid plaques remain continuous and connected to viable cell bodies.
    Brain 132, p402-16.
  • Kerschensteiner M., Reuter M.S., Lichtman J.W. & Misgeld T. (2008) Ex vivo imaging of motor axon dynamics in murine triangularis sterni explants.
    Nature Protocols3, p1645-53.
  • Song J.W., Misgeld T., Kang H., Knecht S., Lu J., Cao Y., Cotman S.L., Bishop D.L. & Lichtman J.W.  (2008) Lysosomal activity associated with developmental axon pruning.
    J Neurosci 28, p8993-9001.
  • Schubert T., Kerschensteiner D., Eggers E.D., Misgeld T., Kerschensteiner M., Lichtman J.W., Lukasiewicz P.D. & Wong R.O. (2008) Development of presynaptic inhibition onto retinal bipolar cell axon terminals is subclass-specific.
    J Neurophysiol 100, p304-16.
  • Misgeld T., Kerschensteiner M., Bareyre F.M., Burgess, R.W. & Lichtman J.W. (2007) In vivo imaging axonal transport of mitochondria in mammals.
    Nature Methods 4, p559-61.
  • Misgeld T., Nikic, I. &  Kerschensteiner M. (2007) In vivo imaging of single axons in the mouse spinal cord.
    Nature Protocols 2, p263-68.
  • Misgeld T. & Kerschensteiner M. (2006) In vivo imaging of the diseased nervous system.
    Nature Reviews Neuroscience 7, p449-63
  • Kummer T.T., Misgeld T. & Sanes J.R. (2006) Assembly of the postsynaptic membrane at the neuromuscular junction: paradigm lost. Current Opinion in Neurobiology 16, p74-82
 

Unsere Webseiten verwenden Cookies zur Verbesserung der Bedienung und des Angebots sowie zur Auswertung von Webseitenbesuchen. Einzelheiten über die von uns eingesetzten Cookies und die Möglichkeit diese abzulehnen, finden Sie in unseren Datenschutzhinweisen.